H673 Degenerative Myelopathy, DM

Degenerative Myelopathy Exon 2 (DM Exon 2)

Canine degenerative myelopathy (DM) is an incurable progressive neurodegenerative disease of the spinal cord. Neurodegenerative diseases are characterised by progressive loss of neurons in the central nervous system (CNS) which leads to deficiencies in function. In the case of DM, the affected region is the spinal cord, which results in ataxia (a loss of coordination). DM is similar in many ways to Amyotrophic Lateral Sclerosis (ALS) in humans.

This variant of the disease, sometimes designated as SOD1B or as Degenerative Myelopathy Exon 2, occurs in many different breeds. It is caused by a recessive mutation to the gene SOD1. A related variant specific to the Bernese Mountain Dog has also been observed. When testing a Bernese Mountain Dog for DM, it is important to test for both of these variants, as opposed to only one.

Degenerative Myelopathy Exon 2 (DM Exon 2) (External Patent Lab)

Canine degenerative myelopathy (DM) is an incurable progressive neurodegenerative disease of the spinal cord. Neurodegenerative diseases are characterised by progressive loss of neurons in the central nervous system (CNS) which leads to deficiencies in function. In the case of DM, the affected region is the spinal cord, which results in ataxia (a loss of coordination). DM is similar in many ways to Amyotrophic Lateral Sclerosis (ALS) in humans.

This variant of the disease, sometimes designated as SOD1B or as Degenerative Myelopathy Exon 2, occurs in many different breeds. It is caused by a recessive mutation to the gene SOD1.

Hereditary Necrotizing Myelopathy (HNM)

Hereditary Necrotising Myelopathy (HNM) is a degenerative neural disease that causes difficulty standing, walking and eating. The disorder is found in the Dutch Kooiker and is caused by a recessive mutation to the gene IBA57.

Degenerativ myelopati Exon 1 (DM Exon 1) – Berner sennenhund

Canine Degenerative Myelopathy (DM) er en uhelbredelig progressiv neurodegenerativ sykdom i ryggmargen. Nevrodegenerative sykdommer kjennetegnes av progressivt tap av nevroner i sentralnervesystemet (CNS) som fører til funksjonsmangler. I tilfelle av DM er den berørte regionen ryggmargen, noe som resulterer i ataksi (tap av koordinering). DM ligner på mange måter amyotrofisk lateral sklerose (ALS) hos mennesker.

Denne varianten av sykdommen, kjent som SOD1A eller som Degenerative Myelopathy Exon 1, forekommer spesielt i Berner Sennenhund. Det er forårsaket av en recessiv mutasjon til genet SOD1. En beslektet variant har blitt observert i et bredt spekter av raser. Når du tester en Berner sennenhund for DM, er det viktig å teste for begge disse variantene, i motsetning til bare en.

Neuronal Ceroid Lipofuscinosis 1 (NCL1) – Dachshund

Neuronal Ceroid Lipofuscinosis (NCL) is a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. The variant analysed in this test, Neuronal Ceroid Lipofuscinosis 1 (NCL1 or CLN1), is caused by a recessive mutation to the gene PPT1, and is found in the Dachshund. Another variant of CLN1 has also been found in the Cane Corso.

Neuronal Ceroid Lipofuscinosis 12 (NCL 12) – Australian Cattle Dog

Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. This variant, occurring in the Australian Cattle Dog, is known as Neuronal Ceroid Lipofuscinosis 12 (NCL12), and is caused by a recessive mutation to the gene ATP13A2. A related variant also occurs in the Tibetan Terrier.

Neuronal Ceroid Lipofuscinosis 2 (NCL2) – Dachshund

Neuronal Ceroid Lipofuscinosis (NCL) is the name for a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. The variant analysed in this test, Neuronal Ceroid Lipofuscinosis 2 (NCL2), is caused by a recessive mutation to the gene TPP1. It is found in the Dachshund.

Neuronal Ceroid Lipofuscinosis 7 (NCL 7)

Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. This variant, known as Neuronal Ceroid Lipofuscinosis 7 (NCL 7) is caused by a recessive mutation to the gene MFSD8, and occurs in the Chinese Crested Dog and Chihuahua.

Neuronal Ceroid Lipofuscinosis 8-1 (NCL8-1) – English Setter

Neuronal Ceroid Lipofuscinosis (NCL) er et bredt spekter av degenerative nevrologiske tilstander som forårsaker progressiv nerveskade, noe som resulterer i tap av bevegelse og syn, og til slutt død. Denne varianten, Neuronal Ceroid Lipofuscinosis type 8 (NCL8), forekommer hos engelsk setter. Den er forårsaket av en recessiv mutasjon i genet CLN8. Andre raser som bærer mutasjoner for NCL8 er alpinsk dachsbrackei, Australian Shepherd, korthåret vorster og Saluki.

Warburg micro syndrome 1 (WARBM1)

Warburg Micro Syndrome, type 1 (WARBM1) is a form of polyneuropathy, a severe degenerative nerve condition that causes vision problems, an altered voice, and lack of coordination. The onset starts at about four months of age, and affected dogs typically need to be euthanized on humane grounds within the first year. The disorder is caused by a recessive mutation to the gene RAB3GAP1, and is found in the Alaskan Husky (this test), and also the Black Russian Terrier and Rottweiler.

Neuronal Ceroid Lipofuscinosis 5 (NCL5)

Neuronal Ceroid Lipofuscinosis (NCL) is the name for a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. The variant analysed in this test, Neuronal Ceroid Lipofuscinosis 5 (NCL5 or CLN5), is caused by a recessive mutation to the gene CLN5. This variant is found in the Australian Cattle Dog and the Border Collie. A related variant is found in the Golden Retriever.

Neuronal ceroid lipofusconisis 4A (NCL 4A) – Amerikansk Staffordshire Terrier

Neuronal ceroid lipofuscinose (NCL) er et bredt spekter av degenerative nevrologiske tilstander som forårsaker progressiv nerveskade, noe som resulterer i tap av mobilitet og syn, og til slutt død.

Denne spesifikke varianten av sykdommen som er analysert i denne testen, kalles Neuronal Ceroid Lipofuscinosis 4A (NCL 4A), Cerebellar Cortical Abiotrophy, Cerebellar Cortical Degeneration, Cerebellar Ataxia eller Mucopolysaccharidosis (MPS). Det forekommer i American Staffordshire Terrier, og er forårsaket av en recessiv mutasjon til genet ARSG.

Neuronal Ceroid Lipofuscinosis 6 (NCL6) – Australian Shepherd

Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. This variant of the disease, known as Neuronal Ceroid Lipofuscinosis 6 (NCL6), is found in the Australian Shepherd, and is caused by a recessive mutation to the gene CLN6.

Neuronal Ceroid Lipofuscinosis 8-2 (NCL8-2)

Neuronal Ceroid Lipofuscinosis (NCL) er et bredt spekter av degenerative nevrologiske tilstander som forårsaker progressiv nerveskade, noe som resulterer i tap av mobilitet og syn, og til slutt død. Denne varianten, Neuronal Ceroid Lipofuscinosis type 8 (NCL8), forekommer i Australian Shepherd og Vorstehhund korthåret. Det er forårsaket av en recessiv mutasjon til genet CLN8. Andre raser som bærer mutasjoner for NCL8 inkludert den Engelske Setteren, Alpinsk Dachsbracke og Saluki

Neuronal Ceroid Lipofuscinosis 8 (NCL8) – Saluki

Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. This particular variant of the disorder, known as Neuronal Ceroid Lipofuscinosis 8 (NCL8), is caused by a recessive mutation to the gene CLN8. The specific mutation analysed in this test is found in the Saluki. Closely related variants also occur in the English Setter, Australian Shepherd, German Shorthaired Pointer and Alpenländische Dachsbracke.

Neuronal Ceroid Lipofuscinosis 5 (NCL5) – Golden Retriever

Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. This variant, occurring in the Golden Retriever, is the result of a recessive mutation to the CLN5 gene. A similar mutation also occurs in the Australian Cattle Dog and Border Collie.

Neuronal Ceroid Lipofuscinosis 1 (NCL1) – Cane Corso

Neuronal Ceroid Lipofuscinosis (NCL) is the name referring to a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. The variant of the disease analysed in this test, known as Neuronal Ceroid Lipofuscinosis 1 (NCL1), is caused by a recessive mutation to the gene PPT1, and is found in the Cane Corso. A closely related variant of NCL1 is found in the Dachshund.

Neuronal Ceroid Lipofuscinosis 10 (NCL10) – American Bulldog

Neuronal Ceroid Lipofuscinosis (NCL) is the name for a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. The variant analysed in this test, Neuronal Ceroid Lipofuscinosis 10 (NCL10), is caused by a recessive mutation to the gene CTSD. It is found in the Amerian Bulldog.

Neuronal Ceroid Lipofuscinosis 12 (NCL12) – Tibetan Terrier

Neuronal Ceroid Lipofuscinosis (NCL) is the name for a wide array of degenerative neurological conditions which cause progressive nerve damage, resulting in a loss of mobility and vision, and ultimately death. The variant analysed in this test, Neuronal Ceroid Lipofuscinosis 12 (NCL12), is caused by a recessive mutation to the gene ATP13A2. It is found in the Tibetan Terrier. A related variant is also found in the Australian Cattle Dog.

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