cavalier/info-lgs@agrotis.it - Page 2 of 5

Random Parentage Verification 6-10 Kittens (Belgium)

With the Random Parentage Verification 6-10 Kittens (Belgium), you can verify the parentage of your kittens. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of six to ten kittens, with two kittens randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the kittens and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected kittens against the alleged parents.
You will only receive a parentage verification report for the randomly tested kittens If the parentage of the randomly selected kitten(s) is excluded, you need to request a parentage verification test for each individual kitten in the litter.

Random Parentage Verification >10 Kittens (Belgium)

With the Random Parentage Verification >10 Kittens (Belgium), you can verify the parentage of your kittens. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of ten kittens and more, with three kittens randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the kittens and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected kittens against the alleged parents.
You will only receive a parentage verification report for the randomly tested kittens If the parentage of the randomly selected kitten(s) is excluded, you need to request a parentage verification test for each individual kitten in the litter.

Random Parentage Verification 6-10 Puppies (Belgium)

With the Random Parentage Verification 6-10 Puppies (Belgium), you can verify the parentage of your puppies. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of six to ten puppies, with two puppies randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the puppies and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected puppies against the alleged parents.
You will only receive a parentage verification report for the randomly tested puppies. If the parentage of the randomly selected puppy or puppies is excluded, you need to request a parentage verification test for each individual puppy in the litter.

Random Parentage Verification >10 Puppies (Belgium)

With the Random Parentage Verification >10 Puppies (Belgium), you can verify the parentage of your puppies. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of ten pupies and more, with three puppies randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the puppies and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected puppies against the alleged parents.
You will only receive a parentage verification report for the randomly tested puppies. If the parentage of the randomly selected puppy or puppies is excluded, you need to request a parentage verification test for each individual puppy in the litter.

Random Parentage Verification 1-5 Puppies (Belgium)

With the Random Parentage Verification 1-5 Puppies (Belgium), you can verify the parentage of your puppies. This test is specifically set-up to comply with Flemish legislation. It uses ISAG 2020 SNP technology, a reliable and globally recognized method for parentage verification in animals. This test is suitable for litters of one to five puppies, with one puppy randomly selected from the litter for parentage verification.

To conduct this test, you will need a special form available through the Flemish associations. We kindly ask you to provide the swabs labeled with microchip numbers and the form signed by a veterinarian, including all details of the puppies and parents. For this test, it is essential that an ISAG 2020 SNP profile is on file for both parents. If a DNA profile is not yet available for one or both parent animals, these must be ordered additionally. The test verifies the parentage of the randomly selected puppy against the alleged parents.
You will only receive a parentage verification report for the randomly tested puppy. If the parentage of the randomly selected puppy is excluded, you need to request a parentage verification test for each individual puppy in the litter.

Lundehund syndrom – LS

The Lundehund breed is predisposed to Lundehund Syndrome (LS), a unique gastro-intestinal disease. Lundehund Syndrome varies in severity, ranging from minor recurrent diarrhea to severe inflammation resulting in death or necessitating euthanasia on humane grounds. It can be partially treated with anti-inflammatory drugs, specialized diets and vitamin supplements.

While the precise cause of the disease is still being studied, it is in part associated with a recessive defect to the gene P3H2 (also known as LEPREL1).

Malign hypertermi (MH) – Hund

Malignant Hyperthermia (MH) is a disorder that affects skeletal muscle function during anaesthesia. It typically remains unnoticed unless triggered, most often by certain anesthetic drugs. When activated, it can cause a rapid and severe reaction involving abnormal muscle activity and dangerously accelerated metabolism. MH is caused by a mutation in the RYR1 gene and is inherited in an autosomal dominant manner. This mutation has been identified in several breeds, including Doberman, Labrador Retriever, Rough Collie, Smooth Collie and German Shepherd.

Autosomal, dominant mutation

Autosomal, dominant arvegang betyr at et dyr kan være fri (normal homozygot), affisert (unormal homozygot) eller bærer (heterozygot). Carriers and affected will both have the symptoms of the mutation.

Forklaring for oppdrettere:
Dyret er FRI/NORMAL og har to friske alleler (normal homozygot). The animal will not acquire any symptoms.
• An animal is a CARRIER and has one healthy allele and one defective allele (heterozygote). Dyret vil utvikle symptomer på sykdommen.
• An animal is AFFECTED and therefore has two defective alleles (abnormal homozygote). Dyret vil utvikle symptomer på sykdommen.

Explanation for breeders:
• An animal is CLEAR/NORMAL, and in that case will have two healthy alleles (normal homozygote). This animal will not acquire any abnormalities when breeding and cannot pass on the abnormality to the next generation.
• An animal is a CARRIER, where it will have a healthy allele and a defective allele (heterozygote). Halvparten av dyrets avkom vil arve det muterte (defekte) genet. Carriers can themselves also become sick.
• An animal is a AFFECTED, which means it has two defective alleles (abnormal homozygote). Avkom etter et affisert individ vil arve mutasjonen og selv utvikle symptom på sykdommen.

Inheritance autosomal dominant:	Foreldre:	Reproductive cells:	Offspring:	Interpretation breeding:	Interpretatie veterinatian:
NORMAL x NORMAL	AA and AA	A/A x A/A	100 % AA	100 % NORMAL	100 % FRISK
NORMAL x CARRIER	AA og AB	A/A x A/B	50% AA 50% AB	50% NORMAL 50% CARRIER	50% HEALTY 50% AFFECTED
NORMAL x AFFISERT	AA and BB	A/A x B/B	100 % AB	100 % BÆRER	100 % AFFISERT
CARRIER x CARRIER	AB og AB	A/B x A/B	25% AA 50% AB 25% BB	25% NORMAL 50% CARRIER 25% AFFECTED	25% HEALTHY 75% AFFECTED
BÆRER x AFFISERT	AB og BB	A/B x B/B	50% AB 50% BB	50% CARRIER 50% AFFECTED	100 % AFFISERT
AFFECTED x AFFECTED	BB og BB	B/B x B/B	100 % BB	100 % AFFISERT	100 % AFFISERT

Australsk Labradoodle dystrofinopati

Muscular Dystrophy (MD) is an X-linked muscular disorder, equivalent to Duchenne Muscular Dystrophy (DMD) in humans. The disorder is severe and ultimately fatal, and causes progressive degradation of the dog’s muscles. It is caused by an X-linked recessive mutation to the DMD gene.

The variant of the disorder analysed in this test is found in the Australian Labradoodle. It is also occasionally known as Australian Labradoodle Dystrophinopathy.

Craniomandibular Osteopathy (CMO) – Weimaraner

Craniomandibular Osteopathy (CMO), sometimes referred to as “lion’s jaw,” is a developmental bone disorder that affects the skull and jaw bones of young, growing dogs. It is caused by a mutation in the SLC35D1 gene. It has been observed in individual cases within the Weimaraner breed, but the inheritance pattern remains unconfirmed.

Pelsfarge Frame Overo – OLWS

Frame Overo Lethal White Syndrome (OLWS) is a lethal condition associated with the frame overo or overo white spotting pattern. It is an incompletely dominant inherited syndrome seen in foals born to parents with the frame overo coat-pattern lineage. The frame overo pattern can vary widely, ranging from horses with very minimal white markings to those with extensive white. This condition is linked to a mutation in the endothelin B receptor gene (EDNRB), which plays a critical role in the proper development of both pigment and nerve cells during development of the embryo.

Pelsfarge A-locus (Agouti) – hest

The Coat Colour A-Locus, or agouti signaling protein (ASIP) gene, controls the distribution of black pigment in horses. ASIP interacts with the MC1R gene, which is associated with the production and balance of black and red pigments. This mutation is classified as a loss-of-function mutation, meaning the recessive allele produces a nonfunctional protein.

Genetic testing for the agouti gene helps breeders identify horses that carry or possess two copies of the recessive allele, which can result in offspring with a black base coat. However, for a horse to be fully black, it must also carry at least one dominant allele of the E-locus. Testing for the E-locus is available with test code P904.

Hereditary Ataxia (SCA) – Australian Shepherd

Progressive Degenerative Myeloencephalopathy is a form of hereditary ataxia, sometimes referred to as spinocerebellar ataxia (SCA). This severe neurological disorder leads to a loss of coordination, muscle weakness, and sensory impairments. It is caused by a recessive mutation in the PNPLA8 gene. As the disease progresses, affected dogs may experience a significantly diminished quality of life, often leading to euthanasia. This variant specifically affects Australian Shepherds.

Goniodysgenese og glaukom (GG)

Goniodysgenesis and Glaucoma (GG) affects the development of the eye’s drainage system. It is caused by an autosomal recessive mutation in the Olfactomedin-Like 3 (OLFML3 gene). This gene is involved in the creation of a protein that supports cell structure and is involved in blood vessel formation. Specifically in Border Collies, affected dogs are at severe high risk for having a malformed or partially closed drainage angle, which prevents fluid from exiting the eye properly. This is called goniodysgenesis and can lead to glaucoma, though the effect of the mutation is variable.

Haemophilia A (HEMA-1) – German Shepherd

Haemophilia A, also known as Factor VIII Deficiency, is the most prevalent bleeding disorder in dogs. This X-linked recessive condition is triggered by a mutation in the gene F8, which severely compromises the blood’s clotting ability. Dogs affected by Haemophilia A may exhibit symptoms like spontaneous internal bleeding or uncontrolled bleeding following injuries or surgical procedures. These manifestations are a result of the impaired clotting mechanism in the bloodstream. As an X-linked recessive disorder, it predominantly affects male dogs, while female dogs usually act as carriers.
This specific variant is found in the German Shepherd and is known as HEMA-1. A different variant is found in other breeds including the Irish Setter, Miniature Schnauzer, Boxer, Old English Sheepdog, and the Rhodesian Ridgeback.

Pelsfarge Hvit flekker – W21

The White Spotting coat colour pattern in horses can be caused by any in a wide array of related mutations. The resulting pattern can vary anywhere between white markings on the face and legs, up to a completely white coat. Depending on both breed and pattern, variants of the White Spotting phenotype may be referred to as Splashed White, Dominant White, Tobiano or Sabino, among others.

The specific variant analysed in this test, known as Dominant White 21 (W21), is caused by an autosomal dominant mutation to the gene KIT. It has been observed in the Icelandic horse and the Icelandic word for the pattern is ýruskjóttur.

Pyruvat kinase mangel (PKDef) – West Highland White terrier

Pyruvate Kinase Deficiency (PK Deficiency) is a disorder of the red blood cells, which can result in anaemia and abnormal bone development. It is caused by a recessive mutation to the PKLR gene. The variant analysed in this test is found in the West Highland White Terrier and Cairn Terrier. Related variants are also found in the Basenji, Labrador Retriever, Pug and Beagle.

Polycystisk nyresykdom (PKD) – Bull terrier

Polycystic Kidney Disease (PKD) is a common condition in animals, characterized by the development of cysts in the kidneys over the animal’s lifetime. These cysts exert pressure on healthy kidney tissue, leading to a loss of kidney function. The disease results from an autosomal dominant mutation in the PKD1 gene and is observed in Bull Terriers, where it is also known as Bull Terrier PKD (BTPKD).

Progressiv retinal atrofi (rcd4-PRA)

Progressive Retinal Atrophy (PRA) is a large group of genetic diseases in which the retina gradually degenerates over time, causing a progressive loss of vision. PRA has multiple forms, including Rod-cone-dysplasia type 4 (rcd4-PRA). This form of PRA is caused by an autosomal recessive mutation in the photoreceptor cilium actin regulator (PCARE) gene also known as the C2orf71 and C17H2orf71 gene. It is characterized by late-onset degeneration of vision in dogs.

This form was first identified in Gordon Setters, but has been found in other breeds as well.

Coat Colour Gold (Copper, Sunshine, Extreme Sunshine)

In British Shorthair and Siberian cats, the Gold phenotype is a colour modification of a typical striped tabby coat, lightening it to shades of yellow and orange. The phenotype can be caused by one of several different mutations to the Corin serine peptidatse (CORIN) gene: Sunshine, Extreme Sunshine and Copper.
The three ‘Golden’ mutations are included in this DNA test. Information on the individual tests is available through the links at the DNA tests.

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