Autosomal, dominant arvegang betyr at et dyr kan være fri (normal homozygot), affisert (unormal homozygot) eller bærer (heterozygot). Carriers and affected will both have the symptoms of the mutation.
Forklaring for oppdrettere:
Dyret er FRI/NORMAL og har to friske alleler (normal homozygot). The animal will not acquire any symptoms.
• An animal is a CARRIER and has one healthy allele and one defective allele (heterozygote). Dyret vil utvikle symptomer på sykdommen.
• An animal is AFFECTED and therefore has two defective alleles (abnormal homozygote). Dyret vil utvikle symptomer på sykdommen.
Explanation for breeders:
• An animal is CLEAR/NORMAL, and in that case will have two healthy alleles (normal homozygote). This animal will not acquire any abnormalities when breeding and cannot pass on the abnormality to the next generation.
• An animal is a CARRIER, where it will have a healthy allele and a defective allele (heterozygote). Halvparten av dyrets avkom vil arve det muterte (defekte) genet. Carriers can themselves also become sick.
• An animal is a AFFECTED, which means it has two defective alleles (abnormal homozygote). Avkom etter et affisert individ vil arve mutasjonen og selv utvikle symptom på sykdommen.
| Inheritance autosomal dominant: | Foreldre: | Reproductive cells: | Offspring: | Interpretation breeding: | Interpretatie veterinatian: |
|---|---|---|---|---|---|
| NORMAL x NORMAL | AA and AA | A/A x A/A | 100 % AA | 100 % NORMAL | 100 % FRISK |
| NORMAL x CARRIER | AA og AB | A/A x A/B | 50% AA
50% AB |
50% NORMAL
50% CARRIER |
50% HEALTY
50% AFFECTED |
| NORMAL x AFFISERT | AA and BB | A/A x B/B | 100 % AB | 100 % BÆRER | 100 % AFFISERT |
| CARRIER x CARRIER | AB og AB | A/B x A/B | 25% AA
50% AB 25% BB |
25% NORMAL
50% CARRIER 25% AFFECTED |
25% HEALTHY
75% AFFECTED |
|
BÆRER x AFFISERT |
AB og BB | A/B x B/B | 50% AB
50% BB |
50% CARRIER
50% AFFECTED |
100 % AFFISERT |
| AFFECTED x AFFECTED | BB og BB | B/B x B/B | 100 % BB | 100 % AFFISERT | 100 % AFFISERT |