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Primary Ciliary Dyskinesia (PCD) is a genetic disease that results in defective cilia, the cellular structures responsible for moving fluids such as mucus.
10 Arbeidsdager
Spesifikasjoner
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Generell informasjon
Primary Ciliary Dyskinesia (PCD) is a genetic disease that results in defective cilia, the cellular structures responsible for moving fluids such as mucus. PCD can cause severe and chronic airway infections and fertility problems. This variant of the disorder, found in the Australian Shepherd, is caused by a recessive mutation to the gene STK36.
Kliniske egenskaper
Affected dogs present within the first few months after birth with recurrent, frequent airway infections, typically including repeated bouts of sneezing and yellow or green discharge from the nose. Treatments such as corticosteroids and inhalation therapy can help treat symptoms, but the dog will remain vulnerable to subsequent infections.
Referanser
Pubmed ID: 36786090
Omia ID: 2623