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Polydactyly, also known as Preaxial Polydactyly (PPD) is a developmental abnormality in dogs that causes the growth of extra toes on the hind legs.
10 Arbeidsdager
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Spesifikasjoner
| Breeds | Belgian Malinois, Biewer Terrier, Huntaway, New Zealand Heading Dog, Norwegian Lundehund, Poodle (Standard), Schnauzer (Standard), Beagle, Cocker Spaniel, Rottweiler, Shetland Sheepdog, Shih-Tzu, Yorkshire Terrier |
|---|---|
| Organ | |
| Gene | |
| Specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | Autosomal dominerende |
| Chromosome | 16 |
Generell informasjon
Polydactyly, also known as Preaxial Polydactyly (PPD) is a developmental abnormality in dogs that causes the growth of extra toes on the hind legs. Specifically, polydactyly restores the first toe that was lost over the course of the evolution of the wolf, giving affected dogs a fifth toe known as a “dewclaw”. This specific variant (DC-2) is caused by a dominant mutation to the Limb Development Membrane Protein 1 (LMBR1) gene that affects the expression of the sonic hedgehog (SHH) gene.
This test measures the mutation known as DC-2. Another mutation, DC-1, is found in Sapsari and Tosa dogs.
Kliniske egenskaper
Berørte hunder utvikler en ekstra tå, eller doble sporer, på bakbena.
Tilleggsinformasjon
Referanser
Pubmed ID: 18689889
Year published: 2008
Omia ID: 810
Omia variant ID: