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Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs.
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Spesifikasjoner
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Swab, Blood EDTA, Blood Heparin, Semen, Tissue |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Generell informasjon
Haemophilia A, also called Factor VIII Deficiency, is the most common bleeding disorder in dogs. Caused by an X-linked recessive mutation to the gene F8, the disease strongly impairs the blood’s ability to clot, which can lead to severe symptoms such as spontaneous internal bleeding, or uncontrolled bleeding after injury or surgery. The specific variant of the disease analysed in this test occurs in the Old English Sheepdog. Related variants are also found in the Irish Setter and Miniature Schnauzer, Boxer, German Shepherd, and the Rhodesian Ridgeback.
Kliniske egenskaper
Haemophilia A can result in frequent bleeding of the joints and soft tissues. Common clinical signs in dogs include bleeding from the mouth, subcutaneous and intramuscular haematomas and lameness.
Tilleggsinformasjon
Referanser
Pubmed ID: 27780008
Omia ID: 437