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The White Spotting coat colour pattern in horses can be caused by any in a wide array of related mutations.
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Spesifikasjoner
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 3 |
| Mutation | c.1597T>C |
| Mode of Inheritance | Autosomal ufullstendig dominerende |
| Organ | |
| Specimen | hår, EDTA blod, heparinblod, sæd, vev |
Generell informasjon
The White Spotting coat colour pattern in horses can be caused by any in a wide array of related mutations. The resulting pattern can vary anywhere between white markings on the face and legs, up to a completely white coat. Depending on both breed and pattern, variants of the White Spotting phenotype may be referred to as Splashed White, Dominant White, Tobiano or Sabino, among others.
The specific variant analysed in this test, known as White Spotting 15 (W15), is caused by an incomplete dominant mutation to the gene KIT. It has been observed in the Arabian horse.
Kliniske egenskaper
Most horses with the W15 mutation have a wide blaze, white socks, and patches of white on the belly and torso. At least two W15/W15 foals have been confirmed by genetic testing, but their health and fertility is unknown; one died of unrelated causes as a foal. They are mainly white with some small roany areas of colour.
Tilleggsinformasjon
Pelsfarge har en komplisert nedarving som involverer en kombinasjon av flere forskjellige gener. Testing for en rekke forskjellige loci vil gi den mest komplette prediksjonen av hestens pelsfargegenetikk. Dominant White kan være forårsaket av et bredt spekter av mutasjoner. En hvitmønstret hest som tester som upåvirket for en bestemt mutasjon, vil nesten helt sikkert bli påvirket av en annen.
Referanser
Pubmed ID: 21554354
Year published: 2011
Omia ID: 209
Omia variant ID: 872