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Neuroaxonal dystrophy (NAD) in dogs is an inherited condition that affects the nervous system.
10 Arbeidsdager
Spesifikasjoner
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Svaber, EDTA blod, heparinblod, sæd, vev |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Generell informasjon
Neuroaxonal dystrophy (NAD) in dogs is an inherited condition that affects the nervous system. In the condition, there is swelling of cells in the brain which affect the communication with nerve cells. NAD can be present at birth or develop later in a dog’s life, leading to neurological dysfunction and loss of coordination.
There are multiple variants of mutations known in different breeds. This specific variant of the disorder, found in the Spanish Water Dog, is caused by a recessive mutation to the gene TECPR2.
Kliniske egenskaper
Symptomene starter vanligvis mellom 6-18-måneders alderen, med påfølgende progressiv kognitiv svikt, tap av bevegelsesevne og nedsatt muskelspenning.
Tilleggsinformasjon
Referanser
Pubmed ID: 26555167
Omia ID: 1975