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Neuroaxonal dystrophy (NAD) in dogs is an inherited condition that affects the nervous system.
10 Arbeidsdager
Spesifikasjoner
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Svaber, EDTA blod, heparinblod, sæd, vev |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Generell informasjon
Neuroaxonal dystrophy (NAD) in dogs is an inherited condition that affects the nervous system. In the condition, there is swelling of cells in the brain which affect the communication with nerve cells. NAD can be present at birth or develop later in a dog’s life, leading to neurological dysfunction and loss of coordination.
There are multiple variants of mutations known in different breeds. This lethal variant of the disease, also known as Fetal-Onset Neuroaxonal Dystrophy (FNAD), was first observed in a Schnauzer and Beagle cross. It is caused by a recessive mutation to the gene MFN2.
Kliniske egenskaper
Berørte valper er født med immobiliserte ben og med skoliose i ryggraden. De er ikke i stand til å puste selvstendig, og er enten dødfødte eller dør kort tid etter fødselen.
Tilleggsinformasjon
Referanser
Pubmed ID: 20653033
Omia ID: 2153