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H811

Hyperuricosuria and Hyperuricemia (HUU) is the presence of unusually high amounts of the waste product uric acid in the urine and blood, respectively.

10 Arbeidsdager

Spesifikasjoner

Breeds

Gene

Organ

specimen

Svaber, EDTA blod, heparinblod, sæd, vev
Mode of Inheritance

Chromosome

Also known as

Year Published

Generell informasjon

Hyperuricosuria and Hyperuricemia (HUU) is the presence of unusually high amounts of the waste product uric acid in the urine and blood, respectively. The disorder may lead to urolithiasis (kidney and bladder stones), which in turn can result in potentially severe urinary tract blockages. In dogs, the disorder is caused by a recessive mutation to the gene SLC2A9.

All purebred Dalmatians are homozygous for this mutation, which puts the breed at increased risk for urolithiasis. It has also been observed at lower frequencies in other breeds, such as the Majorca Mastiff.

Kliniske egenskaper

Clinical features are high uric acid levels, which may result in bladder stones.

Symptoms of urinary stones can include straining to urinate, frequent urination, bloody urine and in advanced cases life-threatening urinary tract obstruction. Surgery is often needed to remove the stones. The likelihood of developing urate stones can be reduced by using specialized nutrition.

Tilleggsinformasjon

Referanser

Pubmed ID: 18989453

Omia ID: 1033

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