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Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds.
10 Arbeidsdager
Spesifikasjoner
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Svaber, EDTA blod, heparinblod, sæd, vev |
| Mode of Inheritance | |
| Chromosome | |
| Also known as | |
| Year Published |
Generell informasjon
Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds. A dog that retains too much copper from its diet suffers from copper toxicosis, which causes liver damage and associated negative effects.
In the Bedlington Terrier, a recessive mutation to the gene COMMD1 (also known as MURR1) is known to cause elevated copper levels, resulting in copper toxicosis.
While copper toxicosis also occurs in breeds such as the Doberman and Labrador Retriever, the disorder in those breeds is caused by a mutation to another gene, ATP7B.
Kliniske egenskaper
Kliniske tegn på leverskade som følge av kobbertoksisose kan inkludere en betent lever, anoreksi, oppkast, sløvhet, vekttap, gulsott og hovent underliv.
Kobbertoksisose kan reduseres med et lavt kobber, høyt sink spesialisert diett.
Tilleggsinformasjon
Med dagens rapporter kan det ikke sies at slettingen i COMMD1-genet er den eneste årsaken til kobbertoksikose.
Referanser
Pubmed ID: 16293123
Omia ID: 1988