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Cerebellar Ataxia is a category of often severe neural disorders that cause a loss of physial coordination.
10 Arbeidsdager
Spesifikasjoner
| Breeds | |
|---|---|
| Gene | |
| Organ | |
| specimen | Svaber, EDTA blod, heparinblod, sæd, vev |
| Mode of Inheritance | |
| Chromosome | |
| Year Published |
Generell informasjon
Cerebellar Ataxia is a category of often severe neural disorders that cause a loss of physial coordination. This variant of the disease, known as Cerebellar Abiotrophy, Neonatal Cerebellar Cortical Degeneration (NCCD) or simply Spinocerebellar Ataxia, is found in the Beagle. It is caused by a recessive mutation to the gene SPTBN2. Other variants of the disease have been reported in the Rhodesian Ridgeback, Samoyed, Irish Setter and Coton De Tulear.
Kliniske egenskaper
Affected puppies are unable to walk normally, having a tendency to lean and fall to either side. Other symptoms can include abnormal eye movement and an absent menace response. Depending on the severity of symptoms, euthanasia on humane grounds may be desirable.
Tilleggsinformasjon
Smittsomme eller neoplastiske årsaker kan forårsake lignende symptomer.
Referanser
Pubmed ID: 22781464
Omia ID: 2092