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Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds.
10 Arbeidsdager
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Spesifikasjoner
| Breeds | |
|---|---|
| Gene | |
| Chromosome | 10 |
| Mutation | exon 2 deletion in the COMMD1 gene |
| Mode of Inheritance | Automatisk resessiv |
| Organ | |
| Specimen | Svaber, EDTA blod, heparinblod, sæd, vev |
| Also known as | Wilson disease |
Generell informasjon
Copper Toxicosis, otherwise known as Wilson Disease, is a complex genetic disease that occurs in several different dog breeds. A dog that retains too much copper from its diet suffers from copper toxicosis, which causes liver damage and associated negative effects.
In the Bedlington Terrier, a recessive mutation to the gene COMMD1 (also known as MURR1) is known to cause elevated copper levels, resulting in copper toxicosis.
Kliniske egenskaper
Kliniske tegn på leverskade som følge av kobbertoksisose kan inkludere en betent lever, anoreksi, oppkast, sløvhet, vekttap, gulsott og hovent underliv.
Kobbertoksisose kan reduseres med et lavt kobber, høyt sink spesialisert diett.
Tilleggsinformasjon
Although copper toxicosis in Bedlington Terriers was historically caused by a mutation in COMMD1, selection against this mutation has greatly reduced its prevalence in the breed. However, the ATP7B mutation was already present at low frequency and appears to have been inadvertently selected for. As a result, the ATP7B mutation is now more common than in the past and is responsible for most cases of copper toxicosis in modern Bedlington Terriers.
Referanser
Pubmed ID: 16293123
Year published: 2005
Omia ID: 1988
Omia variant ID: 643